Week 1 features the NFC West’s fiercest clash as the 49ers visit Seattle. San Francisco arrives with a healthy, star-studded offense led by Purdy and friends McCaffrey, Aiyuk, and Kittle, aiming to remind the league their championship window is still wide open. Seattle counters with a revamped attack under a new scheme and Darnold at the helm, with Jaxon Smith-Njigba ready to spark the offense.

Expect a physical, sometimes messy opening half, then SF’s depth, coaching edge, and playmakers pull away. Smith-Njigba could provide the Seahawks a meaningful spark with 70+ receiving yards and a TD, while Purdy, McCaffrey, and Kittle anchor a late surge for the visitors.

Jahmyr Gibbs leads Week 1’s PPR RB rankings for 2025, with Bijan Robinson, Christian McCaffrey, and Derrick Henry rounding out the top tier. De’Von Achane’s Week 1 status looms large as Miami nudges toward a return from a calf issue, while TreVeyon Henderson’s practice strides raise upside for the Patriots. Chase Brown and Zach Charbonnet sit in the next wave, as Kyren Williams and Breece Hall anchor high-floor lineups. Injuries and backfield splits remain key narrative drivers into kickoff.

As updates roll in, the RB landscape remains fluid: Croskey-Merritt’s opener opportunities, Tank Bigsby’s role in Jacksonville, and Gordon II’s late-round potential all shape Week 1 plans. The rankings are refreshed by Nick Mariano and team news feeds, emphasizing readiness and workload signals for 2025 redrafts, best-ball, and DFS alike.